Research and Innovation Services Partner with us Our Technologies Wound Healing Peptide
Wound Healing Peptide
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Background
Poor wound healing after trauma, surgery, acute illness, or chronic disease conditions affects millions of people worldwide each year.
In particular, foot ulcers are a common complication of poorly controlled diabetes. Diabetic foot ulcers (DFUs) respond poorly to treatment and often require limb amputation as a life-saving procedure, adding clinical and psychological consequences of limb loss to morbidity caused by ulcers.
Despite a large variety of wound care products, only 3 products have been approved by the Food and Drug Administration (FDA) for the treatment of diabetic foot ulcers. Of these, 2 are bioengineered skin-cares products, and the third is a growth-factor whose healing rates are 36-50% after 20 weeks. It is critical to develop a better wound dressing material that can promote local tissue regeneration.
The underlying discovery came from study of Opisthorchiasis, which is a tropical disease caused by ingestion of the food-borne parasite Opisthorchis viverrini (also known as the Southeast Asian liver fluke). Ò»±¾µÀresearchers found the parasite secretes a peptide, named Ov-GRN-1, to repair damage it causes in bile ducts from feeding. Ov-GRN-1 belongs to a secreted growth factor family found in a majority of organisms. Granulin-like proteins are heavily involved in wound healing. The original protein has complex knotted protein structure. Ò»±¾µÀresearchers generated sets of synthesised peptides derived from Ov‑GRN-1 and screened them for increased stability, improved production yield, and enhanced activity in vitro and in vivo. Of these, JCU303, a minimal 24-mer peptide was found to have superior wound healing properties, more stability and reduced immunogenic potential compared to the parent protein.
Figure 1.
- Efficacy: 20% faster healing than nearest competitor in animal studies
- Safety: May offer safety advantages
- Indication: Potentially broader indications
- Cost: Peptide manufacturing easier & less expensive than biologics
- Activity
- Stimulates fibroblast migration & proliferation, collagen production
- Accelerates wound re-epithelialisation
- Restores depleted growth factor activity
- Promotes re-vascularisation
Topical treatment of:
- Chronic wounds
- Diabetic foot ulcer
- Pressure Ulcers
- Venous Stasis Ulcers
- Burns
- Surgical wounds
We are seeking partners for continued development of the lead candidate through preclinical development & clinical trials.
Seeking:
- Development partners
- Commercial partner
- Licensing
- University spin out
- Seeking investment
IP Status
- Patent application submitted
Patent
- PCT/AU2017/050959